Package: GMAC
Type: Package
Title: Genomic Mediation Analysis with Adaptive Confounding Adjustment
Version: 3.2
Date: 2025-12-9
Author: Fan Yang [aut], Jiebiao Wang [aut, cre], Lin Chen [aut]
Authors@R: c(person(given = "Fan",
                        family = "Yang",
                        role = "aut"),
                 person(given = "Jiebiao",
                        family = "Wang",
                        role = c("aut", "cre"),
                        email = "randel.wang@gmail.com"),
                 person(given = "Lin",
                        family = "Chen",
                        role = "aut"))
Maintainer: Jiebiao Wang <randel.wang@gmail.com>
Description: Performs genomic mediation analysis with adaptive
        confounding adjustment (GMAC) proposed by Yang et al. (2017)
        <doi:10.1101/gr.216754.116>. It implements large scale
        mediation analysis and adaptively selects potential confounding
        variables to adjust for each mediation test from a pool of
        candidate confounders. The package is tailored for but not
        limited to genomic mediation analysis (e.g., cis-gene mediating
        trans-gene regulation pattern where an eQTL, its cis-linking
        gene transcript, and its trans-gene transcript play the roles
        as treatment, mediator and the outcome, respectively),
        restricting to scenarios with the presence of cis-association
        (i.e., treatment-mediator association) and random eQTL (i.e.,
        treatment).
License: GPL
Depends: parallel
LazyData: TRUE
NeedsCompilation: no
RoxygenNote: 7.3.2
Packaged: 2026-06-09 07:21:08 UTC; root
Repository: https://randel.r-universe.dev
Date/Publication: 2025-12-11 19:10:02 UTC
RemoteUrl: https://github.com/cran/GMAC
RemoteRef: HEAD
RemoteSha: 4fa4eec7c0315308e72486c636a3e786db97c77d